project . 2017 - 2022 . On going

DecodingInfection

Decoding the host-pathogen interspecies crosstalk at a multiparametric single-cell level
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 756653 Call for proposal: ERC-2017-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,500,000 EURFunder Contribution: 1,500,000 EUR
  • Status: On going
  • Start Date
    01 Oct 2017
    End Date
    30 Sep 2022
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Bacterial pathogens remain a significant threat to global health, necessitating a better understanding of host-pathogen biology. While various evidence point to early infection as a key event in the eventual progression to disease, our recent preliminary data show that during this stage, highly adaptable and dynamic host cells and bacteria engage in complex, diverse interactions that contribute to well-documented heterogeneous outcomes of infection. However, current methodologies rely on measurements of bulk populations, thereby overlooking this diversity that can trigger different outcomes. This application focuses on understanding heterogeneity during the firs...
Description
Bacterial pathogens remain a significant threat to global health, necessitating a better understanding of host-pathogen biology. While various evidence point to early infection as a key event in the eventual progression to disease, our recent preliminary data show that during this stage, highly adaptable and dynamic host cells and bacteria engage in complex, diverse interactions that contribute to well-documented heterogeneous outcomes of infection. However, current methodologies rely on measurements of bulk populations, thereby overlooking this diversity that can trigger different outcomes. This application focuses on understanding heterogeneity during the firs...
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