project . 2017 - 2019 . Closed

NANOCANCER

Getting new insights into the radio-sensitization effects of nanoparticles in photon and charged particle therapy

Open Access mandate for Publications and Research Data European Commission

Funder: European CommissionProject code: 748889 Call for proposal: H2020-MSCA-IF-2016
Funded under: H2020 | MSCA-IF-EF-SE Overall Budget: 158,122 EURFunder Contribution: 158,122 EUR
Status: Closed
Start Date
30 Oct 2017
End Date
29 Oct 2019
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Summary
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Description

The use of high-atomic-number nanoparticles (NP) as tumour radio-sensitizers has been recently proposed as a breakthrough in radiotherapy (RT). Numerous biological studies have shown the enhanced effectiveness in tumor cell killing when NP were associated to photon RT and, more recently, to charged particle therapy. However, the mechanisms of action are not clear yet. In addition to the damage due to a possible local dose enhancement (physical effects), the interaction of NP with essential biological macromolecules could lead to changes in the cells (biochemical effects) leading to an amplified effect of the radiation. Within this framework, the main goal of the...

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ALBA-CELLS

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ALBA-CELLS

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