project . 2017 - 2019 . Closed

NANOCANCER

Getting new insights into the radio-sensitization effects of nanoparticles in photon and charged particle therapy
Open Access mandate for Publications and Research Data European Commission
  • Funder: European CommissionProject code: 748889 Call for proposal: H2020-MSCA-IF-2016
  • Funded under: H2020 | MSCA-IF-EF-SE Overall Budget: 158,122 EURFunder Contribution: 158,122 EUR
  • Status: Closed
  • Start Date
    30 Oct 2017
    End Date
    29 Oct 2019
  • Detailed project information (CORDIS)
Description
The use of high-atomic-number nanoparticles (NP) as tumour radio-sensitizers has been recently proposed as a breakthrough in radiotherapy (RT). Numerous biological studies have shown the enhanced effectiveness in tumor cell killing when NP were associated to photon RT and, more recently, to charged particle therapy. However, the mechanisms of action are not clear yet. In addition to the damage due to a possible local dose enhancement (physical effects), the interaction of NP with essential biological macromolecules could lead to changes in the cells (biochemical effects) leading to an amplified effect of the radiation. Within this framework, the main goal of the...
Partners
Description
The use of high-atomic-number nanoparticles (NP) as tumour radio-sensitizers has been recently proposed as a breakthrough in radiotherapy (RT). Numerous biological studies have shown the enhanced effectiveness in tumor cell killing when NP were associated to photon RT and, more recently, to charged particle therapy. However, the mechanisms of action are not clear yet. In addition to the damage due to a possible local dose enhancement (physical effects), the interaction of NP with essential biological macromolecules could lead to changes in the cells (biochemical effects) leading to an amplified effect of the radiation. Within this framework, the main goal of the...
Partners
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