PILLARS offers a three-pillars framework that includes: (1) A comprehensive and empirically solid account of the combined effect of (i) past waves of automation technologies, (ii) recent trends of international fragmentation of production in Global Value Chains (GVCs) and (iii) industrial transformation of European regions on EU labour markets, in terms of employment reconfiguration, skill mismatch and migration. (2) A comprehensive set of forecasting scenarios based on the impact assessment in (1) and projection of (i) industries’ future exposure to emerging automation technologies; (ii) EU regional industrial transformation and (de)specialisation; and (iii) functional reallocation of workers along GVC and migration flows; and (iv) potential skill mismatch resulting from projections of skill demand and supply. (3) A systematic evaluation of current labour market policies, based on smart specialisation, and training policies that allows identifying areas of success and directions to be mitigated. This will lead to proposing a coherent and cohesive policy roadmap that includes a battery of action in different policy areas (innovation, trade, education and training) to achieve Pathways to Inclusive Labour Markets. PILLARS’ ambition to contribute to assess current labour market policies and co-design a new generation of policies for the future of work will be fulfilled by a consortium of top scholars, including partners from Latin America and China; an enthusiastic, international, multidisciplinary stakeholder support to the potential of PILLARS; and a top notch academic advisory board.