project . 2018 - 2023 . On going

PROPHECY

Translational control in infection biology: riboproteogenomics of bacterial pathogens
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 803972 Call for proposal: ERC-2018-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,498,620 EURFunder Contribution: 1,498,620 EUR
  • Status: On going
  • Start Date
    01 Nov 2018
    End Date
    31 Oct 2023
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
My recent findings revealed translation of numerous previously unidentified (small) open reading frames and expression of alternative N-terminal proteoforms when studying bacterial translation. This proposal aims at unraveling the repertoire of bacterial pathogen proteoforms employed to establish a successful infection in a mammalian host cell. While deep sequencing has enabled the study of gene expression at the transcript level in both pathogen and host simultaneously, the depth of sequencing has so far proven to be unsatisfactory. Moreover, the study of bacterial proteome changes upon infection remains highly unexplored because of the higher proteome complexi...
Description
My recent findings revealed translation of numerous previously unidentified (small) open reading frames and expression of alternative N-terminal proteoforms when studying bacterial translation. This proposal aims at unraveling the repertoire of bacterial pathogen proteoforms employed to establish a successful infection in a mammalian host cell. While deep sequencing has enabled the study of gene expression at the transcript level in both pathogen and host simultaneously, the depth of sequencing has so far proven to be unsatisfactory. Moreover, the study of bacterial proteome changes upon infection remains highly unexplored because of the higher proteome complexi...
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