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The objective of this Twinning project is to significantly strengthen the research in Riga Stradins University (RSU; Latvia) in the smart specialization area of Latvia “bio-medicine, medical technologies, and biotechnologies” with application to immunotherapy of cancer through building an up-rising connections with two internationally leading research institutions, Institute of Microbiology, Tumor and Cell Biology, Karolinska Institutet (Sweden) and the Department of General Biophysics, University of Lodz (Poland). Both represent centers of excellence in the design, testing and clinical applications of a wide class of immunotherapeuticals, with focus on technologies exploiting naked nucleic acids.