project . 2021 - 2022 . On going

OncoResist

Genetic and epigenetic resistance to oncogenic transformation of an epithelium
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 893260 Call for proposal: H2020-MSCA-IF-2019
  • Funded under: H2020 | MSCA-IF-EF-ST Overall Budget: 159,815 EURFunder Contribution: 159,815 EUR
  • Status: On going
  • Start Date
    01 Jan 2021
    End Date
    31 Dec 2022
  • Detailed project information (CORDIS)
Description
Oncogenesis is a complex multi-step process that involves the combination of genetic and epigenetic alterations for normal cells to turn into cancerous cells. Remarkably, while some strong oncogenic signals can promote transformation in some cell states, they are completely innocuous to other cell types. My aim is to study this poorly understood phenomena, being my current hypothesis, that intrinsic cell state transformation protection mechanisms are likely to exist. I will use the Drosophila eye primordium epithelium, as I have previously observed that whereas committed epithelial cells over-proliferate in response to abnormal Hippo signalling, undifferentiated...
Description
Oncogenesis is a complex multi-step process that involves the combination of genetic and epigenetic alterations for normal cells to turn into cancerous cells. Remarkably, while some strong oncogenic signals can promote transformation in some cell states, they are completely innocuous to other cell types. My aim is to study this poorly understood phenomena, being my current hypothesis, that intrinsic cell state transformation protection mechanisms are likely to exist. I will use the Drosophila eye primordium epithelium, as I have previously observed that whereas committed epithelial cells over-proliferate in response to abnormal Hippo signalling, undifferentiated...
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