project . 2017 - 2020 . Closed

GlimS

Patient-specific tumour growth model for quantification of mechanical 'markers' in malignant gliomas: Implications for treatment outcomes.
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 753878 Call for proposal: H2020-MSCA-IF-2016
  • Funded under: H2020 | MSCA-IF-GF Overall Budget: 247,840 EURFunder Contribution: 247,840 EUR
  • Status: Closed
  • Start Date
    01 Jun 2017
    End Date
    31 May 2020
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Gliomas are the most frequent primary brain tumours in adults (70%) with Glioblastoma multiforme (GBM) being the most frequent and most malignant sub-type (about 50%). Their growth is characterised by infiltration of surrounding healthy tissue, rapid proliferation, and the formation of a necrotic core. GBM growth often creates biomechanical forces that cause compression and displacement of the surrounding brain tissue. This mass-effect is of direct clinical importance; it correlates to functional loss and pressure-induced brain herniation is the leading cause of death for 73% of patients, however this is not used to inform treament. Overall long term prognosis f...
Partners
Description
Gliomas are the most frequent primary brain tumours in adults (70%) with Glioblastoma multiforme (GBM) being the most frequent and most malignant sub-type (about 50%). Their growth is characterised by infiltration of surrounding healthy tissue, rapid proliferation, and the formation of a necrotic core. GBM growth often creates biomechanical forces that cause compression and displacement of the surrounding brain tissue. This mass-effect is of direct clinical importance; it correlates to functional loss and pressure-induced brain herniation is the leading cause of death for 73% of patients, however this is not used to inform treament. Overall long term prognosis f...
Partners
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