project . 2019 - 2021 . On going

mAMBo

The role of ASCL1 and MYCN in human brain development
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 841157 Call for proposal: H2020-MSCA-IF-2018
  • Funded under: H2020 | MSCA-IF-EF-ST Overall Budget: 212,934 EURFunder Contribution: 212,934 EUR
  • Status: On going
  • Start Date
    01 May 2019
    End Date
    30 Apr 2021
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
The evolutionary expansion of the neocortex in the primate lineage, and particularly in humans, underpins our higher cognitive abilities. Neural stem and progenitor cells (NPCs) show increased duration of proliferative phases in humans when compared to other mammals and particularly mice. However, the mechanisms responsible for these evolutionary differences in progenitor properties are poorly understood. In this study, I aim to explore the function of the ASCL1 and MYCN proteins in human NPCs. These two factors are crucial to promote proliferation in different NPC populations of the mouse forebrain, but their function in promoting proliferation of human NPCs, w...
Description
The evolutionary expansion of the neocortex in the primate lineage, and particularly in humans, underpins our higher cognitive abilities. Neural stem and progenitor cells (NPCs) show increased duration of proliferative phases in humans when compared to other mammals and particularly mice. However, the mechanisms responsible for these evolutionary differences in progenitor properties are poorly understood. In this study, I aim to explore the function of the ASCL1 and MYCN proteins in human NPCs. These two factors are crucial to promote proliferation in different NPC populations of the mouse forebrain, but their function in promoting proliferation of human NPCs, w...
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