project . 2020 - 2022 . On going

TorsionAtLamina

TWISTING THE BOUNDARIES: ROLE OF TOPOISOMERASE 1 AT THE NUCLEAR LAMINA
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 838555 Call for proposal: H2020-MSCA-IF-2018
  • Funded under: H2020 | MSCA-IF-EF-ST Overall Budget: 175,572 EURFunder Contribution: 175,572 EUR
  • Status: On going
  • Start Date
    01 Sep 2020
    End Date
    31 Aug 2022
  • Detailed project information (CORDIS)
Description
When DNA is transcribed or replicated, torsional stress accumulates on the double helix. This tension must be dissipated by spreading it along the DNA fiber, or it must be removed altogether. One of the main factors responsible for the removal of such stress is DNA Topoisomerase I (Top1), an important target of cancer chemotherapy. When Top1 activity is lost, torsional stress accumulates on transcriptionally active genes and can lead to the formation of non-canonical DNA/RNA hybrid structures called R loops. These structures are emerging as important regulators of genome function and stability. By genome-wide mapping of R loops in human cells, I recently found t...
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Description
When DNA is transcribed or replicated, torsional stress accumulates on the double helix. This tension must be dissipated by spreading it along the DNA fiber, or it must be removed altogether. One of the main factors responsible for the removal of such stress is DNA Topoisomerase I (Top1), an important target of cancer chemotherapy. When Top1 activity is lost, torsional stress accumulates on transcriptionally active genes and can lead to the formation of non-canonical DNA/RNA hybrid structures called R loops. These structures are emerging as important regulators of genome function and stability. By genome-wide mapping of R loops in human cells, I recently found t...
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