project . 2017 - 2022 . On going

EndoMitTalk

Endolysosomal-mitochondria crosstalk in cell and organism homeostasis
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 715322 Call for proposal: ERC-2016-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,498,620 EURFunder Contribution: 1,498,620 EUR
  • Status: On going
  • Start Date
    01 Mar 2017
    End Date
    28 Feb 2022
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
For many years, mitochondria were viewed as semiautonomous organelles, required only for cellular energetics. This view has been displaced by the concept that mitochondria are fully integrated into the life of the cell and that mitochondrial function and stress response rapidly affect other organelles, and even other tissues. A recent discovery from my lab demonstrated that mitochondrial metabolism regulates lysosomal degradation (Cell Metabolism, 2015), thus opening the way to investigate the mechanism behind communication between these organelles and its consequences for homeostasis. With this proposal, we want to assess how mitochondrial crosstalk with endoly...
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Description
For many years, mitochondria were viewed as semiautonomous organelles, required only for cellular energetics. This view has been displaced by the concept that mitochondria are fully integrated into the life of the cell and that mitochondrial function and stress response rapidly affect other organelles, and even other tissues. A recent discovery from my lab demonstrated that mitochondrial metabolism regulates lysosomal degradation (Cell Metabolism, 2015), thus opening the way to investigate the mechanism behind communication between these organelles and its consequences for homeostasis. With this proposal, we want to assess how mitochondrial crosstalk with endoly...
Partners
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