During the last decades, supply chains have become huge networks of heterogeneous organisations involved in the manufacturing and delivery of products to end users. The appearance of IoT is transforming every sector subject to be digitalized. After a period of evaluation of the use of IoT, companies are now moving to complete digitalization of their supply chains. Under this paradigm, iNGENIOUS (Next-GENeration IoT sOlutions for the Universal Supply chain) will exploit some of the most innovative and emerging technologies in line with the standardised trend, contributing to the Next-Generation IoT (NG-IoT) and proposing technical and business enablers to build a complete platform for supply chain management. iNGENIOUS embraces the 5G Infrastructure Association (5G IA) and Alliance for Internet of Things Innovation (AIOTI) vision for empowering smart manufacturing and smart mobility verticals. The iNGENIOUS network layer brings new smart 5G-based IoT functi¬onalities, federated Multi-Access Edge Computing (MEC) nodes and smart orchestration, needed for enabling the projected real-time capable use cases of the supply chain. Security and data management are fully recognized as important features in the project. iNGENIOUS will create a holistic security architecture for next-generation IoT built on neuromorphic sensors with security governed by Artificial Intelligence (AI) algorithms and tile-based hardware architectures based on security by design and isolation by default. In the application layer, iNGENIOUS new AI mechanisms will allow more precise predictions than conventional systems. Project outcomes will be validated into 4 large-scale Proof of Concept demonstration, covering 1 factory, 2 ports, and 1 ship, encompassing 6 uses cases. iNGENIOUS is formed by 21 partners from eight countries, including three telecom vendors and manufacturers, two network operators, four logistics partners, two universities, three research institutes and seven high-tech SMEs.