project . 2021 - 2026 . On going

BALDER

Bioactive peptides from human brown fat cells mediating metabolic control
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 101002725 Call for proposal: ERC-2020-COG
  • Funded under: H2020 | ERC | ERC-COG Overall Budget: 2,000,000 EURFunder Contribution: 2,000,000 EUR
  • Status: On going
  • Start Date
    01 May 2021
    End Date
    30 Apr 2026
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Obesity is an increasing problem where the central nervous system (CNS) plays a major role by regulating food intake. This regulation is based on feedback systems from peripheral organs, including adipose tissue. Brown adipose tissue (BAT) is a subtype of adipose tissue that produces heat in response to cold by switching from an idle state to a highly energy-consuming state. BAT also secretes signalling molecules called batokines, but the biological effects of batokines on distal tissues are unclear. My overall hypothesis is that the energetic state of BAT will be communicated to the CNS, via batokines, to mediate appetite control, in a BAT-brain axis. To test t...
Description
Obesity is an increasing problem where the central nervous system (CNS) plays a major role by regulating food intake. This regulation is based on feedback systems from peripheral organs, including adipose tissue. Brown adipose tissue (BAT) is a subtype of adipose tissue that produces heat in response to cold by switching from an idle state to a highly energy-consuming state. BAT also secretes signalling molecules called batokines, but the biological effects of batokines on distal tissues are unclear. My overall hypothesis is that the energetic state of BAT will be communicated to the CNS, via batokines, to mediate appetite control, in a BAT-brain axis. To test t...
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