project . 2021 - 2023 . On going

iMAC

Synaptic input mapping during cortical map plasticity
Open Access mandate for Publications and Research DataOpen Access mandate for ... European Commission
  • Funder: European CommissionProject code: 101025483 Call for proposal: H2020-MSCA-IF-2020
  • Funded under: H2020 | MSCA-IF-EF-ST Overall Budget: 191,149 EURFunder Contribution: 191,149 EUR
  • Status: On going
  • Start Date
    15 Apr 2021
    End Date
    14 Apr 2023
  • Detailed project information (CORDIS)
Description
The rodent primary somatosensory cortex (S1) contains a malleable topographic map, in which cortical columns functionally represent individual facial whiskers. When all whiskers but two are trimmed, the cortical representations of the two spared whiskers partially fuse. This fusion is associated and possibly facilitated by an increase in NMDAR-mediated dendritic nonlinearities (plateau potentials) in L2/3 neurons, which are dependent on inputs from the higher-order posteromedial thalamic complex (POm). It has been shown that plateau potentials generated by these inputs can promote plasticity of sensory-related synaptic inputs. However, the spatiotemporal relatio...
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Description
The rodent primary somatosensory cortex (S1) contains a malleable topographic map, in which cortical columns functionally represent individual facial whiskers. When all whiskers but two are trimmed, the cortical representations of the two spared whiskers partially fuse. This fusion is associated and possibly facilitated by an increase in NMDAR-mediated dendritic nonlinearities (plateau potentials) in L2/3 neurons, which are dependent on inputs from the higher-order posteromedial thalamic complex (POm). It has been shown that plateau potentials generated by these inputs can promote plasticity of sensory-related synaptic inputs. However, the spatiotemporal relatio...
Partners
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