project . 2016 - 2021 . On going

PhageResist

Beyond CRISPR: Systematic characterization of novel anti-phage defense systems in the microbial pan-genome
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 681203 Call for proposal: ERC-2015-CoG
  • Funded under: H2020 | ERC | ERC-COG Overall Budget: 2,000,000 EURFunder Contribution: 2,000,000 EUR
  • Status: On going
  • Start Date
    01 Jul 2016
    End Date
    31 Dec 2021
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
The perpetual arms race between bacteria and phage has resulted in the evolution of efficient resistance systems that protect bacteria from phage infection. Such systems, which include restriction enzymes and CRISPR-Cas, have major influence on the evolution of both bacteria and phage, and have also proven to be invaluable for molecular and biotechnological applications. Although much have been learned on the biology of bacterial defense against phage, more than half of all sequenced bacteria do not contain CRISPR-Cas, and it is estimated that many additional, yet-uncharacterized anti-phage defense systems are encoded in bacterial genomes. The goal of this proje...
Description
The perpetual arms race between bacteria and phage has resulted in the evolution of efficient resistance systems that protect bacteria from phage infection. Such systems, which include restriction enzymes and CRISPR-Cas, have major influence on the evolution of both bacteria and phage, and have also proven to be invaluable for molecular and biotechnological applications. Although much have been learned on the biology of bacterial defense against phage, more than half of all sequenced bacteria do not contain CRISPR-Cas, and it is estimated that many additional, yet-uncharacterized anti-phage defense systems are encoded in bacterial genomes. The goal of this proje...
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