project . 2021 - 2026 . On going

DEUSBIO

Deciphering and Engineering the overlooked but Universal phenomenon of Subpopulations in BIOtechnology
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 949080 Call for proposal: ERC-2020-STG
  • Funded under: H2020 | ERC | ERC-STG Overall Budget: 1,500,000 EURFunder Contribution: 1,500,000 EUR
  • Status: On going
  • Start Date
    01 Mar 2021
    End Date
    28 Feb 2026
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
Microbial bioproduction, despite being considered a paradigmatic sustainable alternative to petroleum-based chemistry, is often limited by low yields and productivities, which prevents commercialisation. It is generally known for all types of cells that genetically identical populations can form metabolically distinct subpopulations. This diversity strongly impairs bioproduction as the presence of low-producer or slow-grower cells reduces overall yields. However, the universal phenomenon of subpopulations emergence has been largely overlooked, especially in biotechnology, due to technical difficulties. Now, thanks to recent developments in single cell technologi...
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Description
Microbial bioproduction, despite being considered a paradigmatic sustainable alternative to petroleum-based chemistry, is often limited by low yields and productivities, which prevents commercialisation. It is generally known for all types of cells that genetically identical populations can form metabolically distinct subpopulations. This diversity strongly impairs bioproduction as the presence of low-producer or slow-grower cells reduces overall yields. However, the universal phenomenon of subpopulations emergence has been largely overlooked, especially in biotechnology, due to technical difficulties. Now, thanks to recent developments in single cell technologi...
Partners
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