project . 2017 - 2019 . Closed

NMR4Nanos

Development and application of NMR-based tools to inorganic nanocarriers for effective vaccine delivery
Open Access mandate for Publications European Commission
  • Funder: European CommissionProject code: 703374 Call for proposal: H2020-MSCA-IF-2015
  • Funded under: H2020 | MSCA-IF-EF-ST Overall Budget: 172,800 EURFunder Contribution: 172,800 EUR
  • Status: Closed
  • Start Date
    04 Sep 2017
    End Date
    03 Sep 2019
  • Detailed project information (CORDIS)
  • Open Access mandate
    Research Data: No
Description
There is an urgent need for new vaccines, but avoiding side effects is crucial for patient compliance. To address this, new generation vaccines with safe, but weakly immunogenic antigens are formulated with carriers and adjuvants to induce the desired immunological response. Inorganic nanoparticles (NP) have shown potential as carriers while immune stimulators of microbial origin are proven to ensure long lasting immune response. Their successful integration into nanovaccines requires thorough analysis of the inorganic/organic interface. Solution state NMR spectroscopy has recently been established as a potent characterisation tool towards this end. My objective...
Description
There is an urgent need for new vaccines, but avoiding side effects is crucial for patient compliance. To address this, new generation vaccines with safe, but weakly immunogenic antigens are formulated with carriers and adjuvants to induce the desired immunological response. Inorganic nanoparticles (NP) have shown potential as carriers while immune stimulators of microbial origin are proven to ensure long lasting immune response. Their successful integration into nanovaccines requires thorough analysis of the inorganic/organic interface. Solution state NMR spectroscopy has recently been established as a potent characterisation tool towards this end. My objective...
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