The purpose of this proposal is to support the organisation of the 2022 edition of the Week of Innovative Regions in Europe. The university Paris-Saclay was chosen to manage, organize and host the conference. The general objectives of WIRE are: • To contribute to research, innovation and regional development policies • To better position regional actors in order to enhance policy formation for effective innovative regional development • To contribute effectively to the future of Europe in relationship to integrative policies, European added value and real interregional cooperation and co-investments It will take place the 11-12-13th May 2022, 500 visitors are expected. It will look for greater synergies between the EU and Member State actions focusing on the priorities of the Horizon Europe programme 2021 - 2027, its headline targets, and the European Research Area. The title of the conference is “Towards a leading Europe in breakthrough innovation” Based on the fact that breakthrough innovation is a key strategic element of economic development in Europe, as well as on the international context, the WIRE conference proposes a reflection in two parts: • The first will be an overview of the tools available in Europe for the development of breakthrough innovation, especially those available at regional levels to help local developments., It will include a reflection on the articulation between actions and fundings at regional/national/European levels. • The second one proposes a declination of these tools to enforce the European strategy of becoming leader in breakthrough innovation for all stakeholders at different levels, and more specifically at regional levels. In this context, some key topics will be addressed:innovations with potential breakthrough and disruptive nature in a regional ecosystem, innovations with scale-up potential that may be too risky for private investors, the questions of fundings and also the relevant level: European? National? Regional ?