Aging and Replicative Senescence Have Related Effects on Human Stem and Progenitor Cells

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Wagner, Wolfgang; Bork, Simone; Horn, Patrick; Krunic, Damir; Walenda, Thomas; Diehlmann, Anke; Benes, Vladimir; Blake, Jonathon; Huber, Franz-Xaver; Eckstein, Volker; Boukamp, Petra; D. Ho, Anthony;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0005846
  • Subject: Medicine | Cell Biology | Hematology | aging | replicative | senescence | effects | progenitor | cells

<div><p>The regenerative potential diminishes with age and this has been ascribed to functional impairments of adult stem cells. Cells in culture undergo senescence after a certain number of cell divisions whereby the cells enlarge and finally stop proliferation. This o... View more
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