A Genome-Wide RNAi Screen in Caenorhabditis elegans Identifies the Nicotinic Acetylcholine Receptor Subunit ACR-7 as an Antipsychotic Drug Target

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Saur, Taixiang; E. DeMarco, Sarah; Ortiz, Angelica; R. Sliwoski, Gregory; Hao, Limin; Wang, Xin; M. Cohen, Bruce; A. Buttner, Edgar;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pgen.1003313
  • Subject: Biological Sciences | genome-wide | rnai | identifies | nicotinic | acetylcholine | receptor | subunit | acr-7 | antipsychotic | target

<div><p>We report a genome-wide RNA interference (RNAi) screen for Suppressors of Clozapine-induced Larval Arrest (<i>scla</i> genes) in <i>Caenorhabditis elegans</i>, the first genetic suppressor screen for antipsychotic drug (APD) targets in an animal. The screen iden... View more
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