HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study

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J. Henrich, Timothy; Hatano, Hiroyu; Bacon, Oliver; Hogan, Louise E.; Rutishauser, Rachel; Hill, Alison; F. Kearney, Mary; M. Anderson, Elizabeth; P. Buchbinder, Susan; Cohen, Stephanie E.; Abdel-Mohsen, Mohamed; Pohlmeyer, Christopher W.; Fromentin, Remi; Hoh, Rebecca; Y. Liu, Albert; M. McCune, Joseph; Spindler, Jonathan; Metcalf-Pate, Kelly; Hobbs, Kristen S.; Thanh, Cassandra; Gibson, Erica A.; Kuritzkes, Daniel R.; Siliciano, Robert F.; W. Price, Richard; D. Richman, Douglas; Chomont, Nicolas; D. Siliciano, Janet; W. Mellors, John; A. Yukl, Steven; N. Blankson, Joel; ... view all 32 authors
(2017)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pmed.1002417
  • Subject: Medicine | Biotechnology | Immunology | Cancer | Computational Biology | report HIV relapse | HIV persistence | peak plasma HIV RNA | bone marrow | tumor marker CD 30 | antiretroviral therapy | CSF | Rebound plasma HIV sequences | ATI | ART-free HIV remission | PBMC | DNA | culture-based detection methods | humanized mouse outgrowth assay | 4- drug ART intensification | ART-free remission | lymph node tissues | PrEP Participant B | hyperacute infection | HIV RNA | PrEP Participant
    • FOR: 110309 Infectious Diseases | 60506 Virology

<div><p>Background</p><p>It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited from a pre-exposure prophylaxis (PrEP) program who started prophyla... View more
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