HIV-1 persistence following extremely early initiation of antiretroviral therapy (ART) during acute HIV-1 infection: An observational study

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J. Henrich, Timothy ; Hatano, Hiroyu ; Bacon, Oliver ; Hogan, Louise E. ; Rutishauser, Rachel ; Hill, Alison ; F. Kearney, Mary ; M. Anderson, Elizabeth ; P. Buchbinder, Susan ; Cohen, Stephanie E. ; Abdel-Mohsen, Mohamed ; Pohlmeyer, Christopher W. ; Fromentin, Remi ; Hoh, Rebecca ; Y. Liu, Albert ; M. McCune, Joseph ; Spindler, Jonathan ; Metcalf-Pate, Kelly ; Hobbs, Kristen S. ; Thanh, Cassandra ; Gibson, Erica A. ; Kuritzkes, Daniel R. ; Siliciano, Robert F. ; W. Price, Richard ; D. Richman, Douglas ; Chomont, Nicolas ; D. Siliciano, Janet ; W. Mellors, John ; A. Yukl, Steven ; N. Blankson, Joel ... view all 32 authors (2017)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pmed.1002417
  • Subject: Medicine | Biotechnology | Immunology | Cancer | Computational Biology | report HIV relapse | HIV persistence | peak plasma HIV RNA | bone marrow | tumor marker CD 30 | antiretroviral therapy | CSF | Rebound plasma HIV sequences | ATI | ART-free HIV remission | PBMC | DNA | culture-based detection methods | humanized mouse outgrowth assay | 4- drug ART intensification | ART-free remission | lymph node tissues | PrEP Participant B | hyperacute infection | HIV RNA | PrEP Participant
    • FOR: 110309 Infectious Diseases | 60506 Virology

<div><p>Background</p><p>It is unknown if extremely early initiation of antiretroviral therapy (ART) may lead to long-term ART-free HIV remission or cure. As a result, we studied 2 individuals recruited from a pre-exposure prophylaxis (PrEP) program who started prophyla... View more
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