Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice

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Federico, Lorenzo ; Yang, Liping ; Brandon, Jason ; Panchatcharam, Manikandan ; Ren, Hongmei ; Mueller, Paul ; Sunkara, Manjula ; Escalante-Alcalde, Diana ; Morris, Andrew J. ; S. Smyth, Susan
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0198063
  • Subject: Biochemistry | Cell Biology | Genetics | Molecular Biology | Physiology | Developmental Biology | Computational Biology | adipocyte sphingolipid synthesis | diet-dependent sphingolipid synthesis | diet-induced adipose tissue expansion | adipocyte lipid metabolism | lipid phosphatase activity | LPP 3 | LPP 3 substrate sphingosine 1- phosphate | serine palmitoyl transferase | intracellular PA-specific phosphatases | specificity membrane-associated lipid phosphate phosphatases | LPP 3 deficiency | Adipocyte LPP 3 deficiency | lipin 1 causes lipodystrophy | Lipid phosphate phosphatase 3 | adipocyte LPP 3 deficiency | Western diet-fed mice
    • FOR: 69999 Biological Sciences not elsewhere classified | 39999 Chemical Sciences not elsewhere classified

<div><p>Dephosphorylation of phosphatidic acid (PA) is the penultimate step in triglyceride synthesis. Adipocytes express soluble intracellular PA-specific phosphatases (Lipins) and broader specificity membrane-associated lipid phosphate phosphatases (LPPs) that can als... View more
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