Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice
Morris, Andrew J.
S. Smyth, Susan
- Publisher: Figshare
Biochemistry | Cell Biology | Genetics | Molecular Biology | Physiology | Developmental Biology | Computational Biology | adipocyte sphingolipid synthesis | diet-dependent sphingolipid synthesis | diet-induced adipose tissue expansion | adipocyte lipid metabolism | lipid phosphatase activity | LPP 3 | LPP 3 substrate sphingosine 1- phosphate | serine palmitoyl transferase | intracellular PA-specific phosphatases | specificity membrane-associated lipid phosphate phosphatases | LPP 3 deficiency | Adipocyte LPP 3 deficiency | lipin 1 causes lipodystrophy | Lipid phosphate phosphatase 3 | adipocyte LPP 3 deficiency | Western diet-fed mice
<div><p>Dephosphorylation of phosphatidic acid (PA) is the penultimate step in triglyceride synthesis. Adipocytes express soluble intracellular PA-specific phosphatases (Lipins) and broader specificity membrane-associated lipid phosphate phosphatases (LPPs) that can als...