Genome-Wide Association Study Using Extreme Truncate Selection Identifies Novel Genes Affecting Bone Mineral Density and Fracture Risk

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L. Duncan, Emma ; Danoy, Patrick ; P. Kemp, John ; J. Leo, Paul ; McCloskey, Eugene ; C. Nicholson, Geoffrey ; Eastell, Richard ; L. Prince, Richard ; A. Eisman, John ; Jones, Graeme ; N. Sambrook, Philip ; R. Reid, Ian ; M. Dennison, Elaine ; Wark, John ; Brent Richards, J. ; G. Uitterlinden, Andre ; D. Spector, Tim ; Esapa, Chris ; D. Cox, Roger ; D. M. Brown, Steve ; V. Thakker, Rajesh ; A. Addison, Kathryn ; A. Bradbury, Linda ; R. Center, Jacqueline ; Cooper, Cyrus ; Cremin, Catherine ; Estrada, Karol ; Felsenberg, Dieter ; Glüer, Claus-C. ; Hadler, Johanna ... view all 47 authors (2011)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pgen.1001372
  • Subject: identifies | Cell Biology | Genetics | genome-wide | truncate | selection | genes | affecting | fracture
    mesheuropmc: musculoskeletal diseases

<div><p>Osteoporotic fracture is a major cause of morbidity and mortality worldwide. Low bone mineral density (BMD) is a major predisposing factor to fracture and is known to be highly heritable. Site-, gender-, and age-specific genetic effects on BMD are thought to be ... View more
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