Identification of Novel Androgen-Regulated Pathways and mRNA Isoforms through Genome-Wide Exon-Specific Profiling of the LNCaP Transcriptome

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Rajan, Prabhakar; Dalgliesh, Caroline; J. Carling, Phillippa; Buist, Thomas; Zhang, Chaolin; N. Grellscheid, Sushma; Armstrong, Kelly; Stockley, Jacqueline; Simillion, Cedric; Gaughan, Luke; Kalna, Gabriela; Q. Zhang, Michael; N. Robson, Craig; Y. Leung, Hing; J. Elliott, David;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0029088
  • Subject: Chemistry | transcriptome | isoforms | pathways | mrna | Genetics | genome-wide | profiling | lncap | Biochemistry | exon-specific | Cancer | androgen-regulated
    mesheuropmc: urologic and male genital diseases

<div><p>Androgens drive the onset and progression of prostate cancer (PCa) by modulating androgen receptor (AR) transcriptional activity. Although several microarray-based studies have identified androgen-regulated genes, here we identify in-parallel global androgen-dep... View more
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