Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma.

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CHALK, ALISTAIR ; WALKLEY, CARL ; BAKER, EMMA ; Gupte, Ankita ; WAN, SOO-SAN ; Stewart, Elizabeth ; Loh, Amos ; Shelat, Anang A. ; M. Gould, Cathryn ; Taylor, Scott ; Lackovic, Kurt ; J. Mutsaers, Anthony ; DESAI, JAYESH ; B. Madhamshettiwa, Piyush ; C.W. Zannettino, Andrew ; Burns, Chris ; HUANG, DAVID ; A. Dyer, Michael ; J. Simpson, Kaylene (2015)
  • Publisher: Figshare
  • Related identifiers: doi: 10.4225/49/559e18efe779f
  • Subject: Cell Biology | Genetics | Molecular Biology | Cancer | Bioinformatics | osteosarcoma | shrna | st vincents instutite | kinase screen | pi3k | mtor | genome-wide screen | primary osteosarcoma cell cultures

<p><a href="http://www.ncbi.nlm.nih.gov/pubmed/25862761" target="_blank">Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma.</a></p><div><pre>PURPOSE: Osteosarcoma is the most common cancer of bone occu... View more
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