The Anti-Repressor MecR2 Promotes the Proteolysis of the mecA Repressor and Enables Optimal Expression of β-lactam Resistance in MRSA

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Arêde, Pedro ; Milheiriço, Catarina ; de Lencastre, Hermínia ; C. Oliveira, Duarte
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.ppat.1002816
  • Subject: Molecular Biology | mrsa | mecr2 | repressor | optimal | Microbiology | anti-repressor | Cell Biology | Genetics | Cancer | promotes | proteolysis | enables
    mesheuropmc: bacterial infections and mycoses | biochemical phenomena, metabolism, and nutrition

<div><p>Methicillin-resistant <em>Staphylococcus aureus</em> (MRSA) is an important human pathogen, which is cross-resistant to virtually all β-lactam antibiotics. MRSA strains are defined by the presence of <em>mecA</em> gene. The transcription of <em>mecA</em> can be ... View more
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