Differential PfEMP1 Expression Is Associated with Cerebral Malaria Pathology

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L. Tembo, Dumizulu; Nyoni, Benjamin; V. Murikoli, Rekah; Mukaka, Mavuto; A. Milner, Danny; Berriman, Matthew; J. Rogerson, Stephen; E. Taylor, Terrie; E. Molyneux, Malcolm; L. Mandala, Wilson; Craig, Alister G.; Montgomery, Jacqui;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.ppat.1004537
  • Subject: Cerebral Malaria Pathology Plasmodium falciparum | cytoadherence ligand | novel examination | malaria | group B var | Differential PfEMP 1 Expression | CM 2 | falciparum erythrocyte membrane protein 1 | host organs | CM 1 | falciparum infections | parasitaemic controls | var genes | CM 1 infections | pcr | PC cases | Biological Sciences | PfEMP 1 groups | organ sample | parasite | variant antigens | var tags | expression patterns | var transcript tags | paediatric hosts
    mesheuropmc: parasitic diseases

<div><p><i>Plasmodium falciparum</i> is unique among human malarias in its ability to sequester in post-capillary venules of host organs. The main variant antigens implicated are the <i>P. falciparum</i> erythrocyte membrane protein 1 (PfEMP1), which can be divided into... View more
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