Presynaptically Localized Cyclic GMP-Dependent Protein Kinase 1 Is a Key Determinant of Spinal Synaptic Potentiation and Pain Hypersensitivity

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Luo, Ceng ; Gangadharan, Vijayan ; Kumar Bali, Kiran ; Xie, Rou-Gang ; Agarwal, Nitin ; Kurejova, Martina ; Tappe-Theodor, Anke ; Tegeder, Irmgard ; Feil, Susanne ; Lewin, Gary ; Polgar, Erika ; J. Todd, Andrew ; Schlossmann, Jens ; Hofmann, Franz ; Liu, Da-Lu ; Hu, San-Jue ; Feil, Robert ; Kuner, Thomas ; Kuner, Rohini
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pbio.1001283
  • Subject: hypersensitivity | Neuroscience | presynaptically | localized | gmp-dependent | synaptic | kinase | spinal | potentiation | cyclic | determinant
    mesheuropmc: cardiovascular system | nervous system

<div><p>Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states. Previous studies have functionally impli... View more
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