Plasmodium vivax Invasion of Human Erythrocytes Inhibited by Antibodies Directed against the Duffy Binding Protein

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T Grimberg, Brian; Udomsangpetch, Rachanee; Xainli, Jia; McHenry, Amy; Panichakul, Tasanee; Sattabongkot, Jetsumon; Cui, Liwang; Bockarie, Moses; Chitnis, Chetan; Adams, John; A Zimmerman, Peter; L King, Christopher;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pmed.0040337
  • Subject: directed | Cell Biology | erythrocytes | inhibited | binding | Cancer | antibodies | duffy
    mesheuropmc: parasitic diseases

<div><h3>Background</h3><p>Plasmodium vivax invasion requires interaction between the human Duffy antigen on the surface of erythrocytes and the P. vivax Duffy binding protein (PvDBP) expressed by the parasite. Given that Duffy-negative individuals are resistant and tha... View more
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