Identification of Estrogen Receptor Dimer Selective Ligands Reveals Growth-Inhibitory Effects on Cells That Co-Express ERα and ERβ

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Powell, Emily; Shanle, Erin; Brinkman, Ashley; Li, Jun; Keles, Sunduz; B. Wisinski, Kari; Huang, Wei; Xu, Wei;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0030993
  • Subject: Biochemistry | Cell Biology | Molecular Biology | Physiology | Chemistry | Biological Sciences | Cancer | estrogen | receptor | dimer | selective | ligands | reveals | growth-inhibitory | effects | cells | co-express

<div><p>Estrogens play essential roles in the progression of mammary and prostatic diseases. The transcriptional effects of estrogens are transduced by two estrogen receptors, ERα and ERβ, which elicit opposing roles in regulating proliferation: ERα is proliferative whi... View more
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