iRegulon: From a Gene List to a Gene Regulatory Network Using Large Motif and Track Collections

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Janky, Rekin's ; Verfaillie, Annelien ; Imrichová, Hana ; Van de Sande, Bram ; Standaert, Laura ; Christiaens, Valerie ; Hulselmans, Gert ; Herten, Koen ; Naval Sanchez, Marina ; Potier, Delphine ; Svetlichnyy, Dmitry ; Kalender Atak, Zeynep ; Fiers, Mark ; Marine, Jean-Christophe ; Aerts, Stein
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pcbi.1003731
  • Subject: Biological Sciences | Computational biology | genome analysis | Transcriptome analysis | genetics | genomics | Network Analysis | Regulatory networks | motif

<div><p>Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network underlying a ... View more
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