Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells
- Publisher: Figshare
Medicine | Cell Biology | Genetics | Molecular Biology | Developmental Biology | Computational Biology | CKO | lens epithelial cells | Sox 1-Cre allele | onset cataract marker proteins | lens fiber regulators | Notch signaling-related genes | lens fiber formation | lens fiber regulator genes | down-regulated expression | Aberrant Terminal Differentiation | Lens Fiber Cells REST | tissue | gene expression analyses | phenotype | co cntrol mice | RE 1-silencing transcription factor
<div><p>REST (RE1-silencing transcription factor, also called Nrsf) is involved in the maintenance of the undifferentiated state of neuronal stem/progenitor cells in vitro by preventing precocious expression of neuronal genes. REST expression was then decreased in devel...