Disruption of Rest Leads to the Early Onset of Cataracts with the Aberrant Terminal Differentiation of Lens Fiber Cells

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Aoki, Hitomi ; Ogino, Hajime ; Tomita, Hiroyuki ; Hara, Akira ; Kunisada, Takahiro
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0163042
  • Subject: Medicine | Cell Biology | Genetics | Molecular Biology | Developmental Biology | Computational Biology | CKO | lens epithelial cells | Sox 1-Cre allele | onset cataract marker proteins | lens fiber regulators | Notch signaling-related genes | lens fiber formation | lens fiber regulator genes | down-regulated expression | Aberrant Terminal Differentiation | Lens Fiber Cells REST | tissue | gene expression analyses | phenotype | co cntrol mice | RE 1-silencing transcription factor
    • FOR: 69999 Biological Sciences not elsewhere classified

<div><p>REST (RE1-silencing transcription factor, also called Nrsf) is involved in the maintenance of the undifferentiated state of neuronal stem/progenitor cells in vitro by preventing precocious expression of neuronal genes. REST expression was then decreased in devel... View more
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