Supplementary Material for: Desmosterol in Brain Is Elevated because DHCR24 Needs REST for Robust Expression but REST Is Poorly Expressed
- Publisher: Figshare
Medicine | Cholesterol | Regulation | Neural tissue | Development | Repressor element 1 sequence | Sterol response element
Cholesterol synthesis in the fetal brain is inhibited because activity of DHCR24 (24-dehydrocholesterol reductase) is insufficient, causing concentrations of the precursor desmosterol to increase temporarily to 15-25% of total sterols at birth. We demonstrate that failu...