Supplementary Material for: Desmosterol in Brain Is Elevated because DHCR24 Needs REST for Robust Expression but REST Is Poorly Expressed

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G.S., Tint ; L., Pan ; Q., Shang ; L.J., Sharpe ; A.J., Brown ; M., Li ; H., Yu
  • Publisher: Figshare
  • Related identifiers: doi: 10.6084/m9.figshare.5126446.v1
  • Subject: Medicine | Cholesterol | Regulation | Neural tissue | Development | Repressor element 1 sequence | Sterol response element

Cholesterol synthesis in the fetal brain is inhibited because activity of DHCR24 (24-dehydrocholesterol reductase) is insufficient, causing concentrations of the precursor desmosterol to increase temporarily to 15-25% of total sterols at birth. We demonstrate that failu... View more
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