Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1

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Ge, Xianpeng ; Ritter, Susan Y. ; Tsang, Kelly ; Shi, Ruirui ; Takei, Kohtaro ; O. Aliprantis, Antonios
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0159157
  • Subject: Biochemistry | Microbiology | Cell Biology | Physiology | Pharmacology | Ecology | Immunology | Developmental Biology | Science Policy | synovial fibroblasts | OA | PCR | DMM | proinflammatory cytokines interleukin -1beta | upregulate CRTAC 1 expression | tumor necrosis factor | Protein 1 Cartilage acidic protein 1 | CRTAC 1
    • FOR: 69999 Biological Sciences not elsewhere classified

<div><p>Cartilage acidic protein 1 (CRTAC1) was recently identified as an elevated protein in the synovial fluid of patients with osteoarthritis (OA) by a proteomic analysis. This gene is also upregulated in both human and mouse OA by transcriptomic analysis. The object... View more
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