Regenerative Capacity of Old Muscle Stem Cells Declines without Significant Accumulation of DNA Damage

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Cousin, Wendy; Liane Ho, Michelle; Desai, Rajiv; Tham, Andrea; Yuzen Chen, Robert; Kung, Sunny; Elabd, Christian; M. Conboy, Irina;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0063528
  • Subject: Biological Sciences | Anatomy and physiology | Musculoskeletal system | muscle | Physiological processes | aging | Biochemistry | Nucleic acids | dna | DNA repair | proteins | DNA-binding proteins | biophysics | Model organisms | Animal models | mouse | Molecular cell biology | Cellular types | Muscle fibers | Muscle cells | cells | declines | accumulation

<div><p>The performance of adult stem cells is crucial for tissue homeostasis but their regenerative capacity declines with age, leading to failure of multiple organs. In skeletal muscle this failure is manifested by the loss of functional tissue, the accumulation of fi... View more
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