Safety and Immunogenicity of Heterologous Prime-Boost Immunisation with Plasmodium falciparum Malaria Candidate Vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, in Healthy Gambian and Kenyan Adults

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Ogwang, Caroline ; Afolabi, Muhammed ; Kimani, Domtila ; Jankey Jagne, Ya ; H. Sheehy, Susanne ; M. Bliss, Carly ; J. A. Duncan, Christopher ; A. Collins, Katharine ; A. Garcia Knight, Miguel ; Kimani, Eva ; A. Anagnostou, Nicholas ; Berrie, Eleanor ; Moyle, Sarah ; C. Gilbert, Sarah ; J. Spencer, Alexandra ; Soipei, Peninah ; Mueller, Jenny ; Okebe, Joseph ; Colloca, Stefano ; Cortese, Riccardo ; K. Viebig, Nicola ; Roberts, Rachel ; Gantlett, Katherine ; M. Lawrie, Alison ; Nicosia, Alfredo ; B. Imoukhuede, Egeruan ; Bejon, Philip ; C. Urban, Britta ; L. Flanagan, Katie ; J. Ewer, Katie ... view all 33 authors (2013)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0057726
  • Subject: Pharmacology | Immunology | Infectious Diseases | immunogenicity | heterologous | prime-boost | immunisation | malaria | chad63 | me-trap | mva | gambian | kenyan | adults

<div><p>Background</p><p>Heterologous prime boost immunization with chimpanzee adenovirus 63 (ChAd63) and Modified vaccinia Virus Ankara (MVA) vectored vaccines is a strategy recently shown to be capable of inducing strong cell mediated responses against several antigen... View more
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