Constitutive Phosphorylation of Aurora-A on Ser51 Induces Its Stabilization and Consequent Overexpression in Cancer
- Publisher: Figshare
Medicine | Cell Biology | Cancer | constitutive | phosphorylation | aurora-a | ser51 | induces | stabilization | consequent | overexpression | cancer
<div><h3>Background</h3><p>The serine/threonine kinase Aurora-A (Aur-A) is a proto-oncoprotein overexpressed in a wide range of human cancers. Overexpression of Aur-A is thought to be caused by gene amplification or mRNA overexpression. However, recent evidence revealed...