Constitutive Phosphorylation of Aurora-A on Ser51 Induces Its Stabilization and Consequent Overexpression in Cancer

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Kitajima, Shojiro ; Kudo, Yasusei ; Ogawa, Ikuko ; Tatsuka, Masaaki ; Kawai, Hidehiko ; Pagano, Michele ; Takata, Takashi (2007)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0000944
  • Subject: Medicine | Cell Biology | Cancer | constitutive | phosphorylation | aurora-a | ser51 | induces | stabilization | consequent | overexpression | cancer

<div><h3>Background</h3><p>The serine/threonine kinase Aurora-A (Aur-A) is a proto-oncoprotein overexpressed in a wide range of human cancers. Overexpression of Aur-A is thought to be caused by gene amplification or mRNA overexpression. However, recent evidence revealed... View more
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