Intramuscular Artesunate for Severe Malaria in African Children: A Multicenter Randomized Controlled Trial

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G. Kremsner, Peter ; A. Adegnika, Akim ; B. Hounkpatin, Aurore ; F. Zinsou, Jeannot ; E. Taylor, Terrie ; Chimalizeni, Yamikani ; Liomba, Alice ; Kombila, Maryvonne ; K. Bouyou-Akotet, Marielle ; P. Mawili Mboumba, Denise ; Agbenyega, Tsiri ; Ansong, Daniel ; Sylverken, Justice ; R. Ogutu, Bernhards ; A. Otieno, Godfrey ; Wangwe, Anne ; A. Bojang, Kalifa ; Okomo, Uduak ; Sanya-Isijola, Frank ; R. Newton, Charles ; Njuguna, Patricia ; Kazungu, Michael ; Kerb, Reinhold ; Geditz, Mirjam ; Schwab, Matthias ; P. Velavan, Thirumalaisamy ; Nguetse, Christian ; Köhler, Carsten ; Issifou, Saadou ; Bolte, Stefanie ... view all 33 authors
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pmed.1001938
  • Subject: Uncategorised | N 86YPfmdr genotype | Multicenter Randomized Controlled Trial BackgroundCurrent artesunate | PACTR | parenteral ARS regimen | parasite clearance kinetics | i.v | i.m | African children.Trial registrationPan | ci | 24 h | analysis

<div><p>Background</p><p>Current artesunate (ARS) regimens for severe malaria are complex. Once daily intramuscular (i.m.) injection for 3 d would be simpler and more appropriate for remote health facilities than the current WHO-recommended regimen of five intravenous (... View more
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