A Pilot Randomised Trial of Induced Blood-Stage Plasmodium falciparum Infections in Healthy Volunteers for Testing Efficacy of New Antimalarial Drugs

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S. McCarthy, James; Sekuloski, Silvana; M. Griffin, Paul; Elliott, Suzanne; Douglas, Nanette; Peatey, Chris; Rockett, Rebecca; O'Rourke, Peter; Marquart, Louise; Hermsen, Cornelius; Duparc, Stephan; Möhrle, Jörg; Trenholme, Katharine R.; J. Humberstone, Andrew;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0021914
  • Subject: randomised | drugs | Microbiology | volunteers | antimalarial | efficacy | blood-stage | Biochemistry | Pharmacology | induced | infections | Cancer
    mesheuropmc: parasitic diseases

<div><h3>Background</h3><p>Critical to the development of new drugs for treatment of malaria is the capacity to safely evaluate their activity in human subjects. The approach that has been most commonly used is testing in subjects with natural malaria infection, a metho... View more
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