Extensive Alternative Splicing of the Repressor Element Silencing Transcription Factor Linked to Cancer

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Chen, Guo-Lin; Miller, Gregory M.;
(2013)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0062217
  • Subject: Physics | Medicine | Biological Sciences | Biochemistry | Nucleic acids | rna | RNA processing | Computational biology | Molecular genetics | Gene regulation | biophysics | genetics | Cancer genetics | epigenetics | Gene splicing | Molecular cell biology | gene expression | epidemiology | Biomarker epidemiology | oncology | Cancer risk factors | Genetic causes of cancer | Basic cancer research | splicing | repressor | transcription | linked

<div><p>The repressor element silencing transcription factor (REST) is a coordinate transcriptional and epigenetic regulator which functions as a tumor suppressor or an oncogene depending on cellular context, and a truncated splice variant REST4 has been linked to vario... View more
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