Differential Susceptibility to Hypertension Is Due to Selection during the Out-of-Africa Expansion

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Hunter Young, J. ; C Chang, Yen-Pei ; Dae-Ok Kim, James ; Chretien, Jean-Paul ; J Klag, Michael ; A Levine, Michael ; B Ruff, Christopher ; Wang, Nae-Yuh ; Chakravarti, Aravinda
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pgen.0010082
  • Subject: Genetics | Physiology | Evolutionary Biology | differential | susceptibility | hypertension | out-of-africa

<div><p>Hypertension is a leading cause of stroke, heart disease, and kidney failure. The genetic basis of blood pressure variation is largely unknown but is likely to involve genes that influence renal salt handling and arterial vessel tone. Here we argue that suscepti... View more
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