Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

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Dogovski, Con; C. Xie, Stanley; Burgio, Gaetan; Bridgford, Jess; Mok, Sachel; M. McCaw, James; Chotivanich, Kesinee; Kenny, Shannon; Gnädig, Nina; Straimer, Judith; Bozdech, Zbynek; Fidock, David A.; Simpson, Julie A.; M. Dondorp, Arjen; Foote, Simon; Klonis, Nectarios; Tilley, Leann;
(2015)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pbio.1002132
  • Subject: K 13 propeller protein | vivo parasite clearance profiles | Plasmodium falciparum sourced | artemisinin combination therapies | Overcome Artemisinin Resistance | Biological Sciences | ubiquitinated proteins | cell stress response | stress response | synergize ART activity | ART treatment courses | ART resistance
    mesheuropmc: parasitic diseases

<div><p>Successful control of falciparum malaria depends greatly on treatment with artemisinin combination therapies. Thus, reports that resistance to artemisinins (ARTs) has emerged, and that the prevalence of this resistance is increasing, are alarming. ART resistance... View more
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