Safety and Immunogenicity of a Recombinant Plasmodium falciparum AMA1 Malaria Vaccine Adjuvanted with Alhydrogel™, Montanide ISA 720 or AS02

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Roestenberg, Meta; Remarque, Ed; de Jonge, Erik; Hermsen, Rob; Blythman, Hildur; Leroy, Odile; Imoukhuede, Egeruan; Jepsen, Soren; Ofori-Anyinam, Opokua; Faber, Bart; H. M. Kocken, Clemens; Arnold, Miranda; Walraven, Vanessa; Teelen, Karina; Roeffen, Will; de Mast, Quirijn; Ripley Ballou, W.; Cohen, Joe; Claude Dubois, Marie; Ascarateil, Stéphane; van der Ven, Andre; Thomas, Alan; Sauerwein, Robert;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0003960
  • Subject: Physics | Microbiology | Immunology | Cancer | immunogenicity | recombinant | ama1 | malaria | adjuvanted | montanide | isa | 720 | as02

<div><h3>Background</h3><p><em>Plasmodium falciparum</em> Apical Membrane Antigen 1 (<em>Pf</em>AMA1) is a candidate vaccine antigen expressed by merozoites and sporozoites. It plays a key role in red blood cell and hepatocyte invasion that can be blocked by antibodies.... View more
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