S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway

Collection UNKNOWN
Wang, Minjun; Tang, Wenbo; Xin, Hong; Zhun Zhu, Yi;
(2016)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0163289
  • Subject: Biochemistry | Microbiology | Molecular Biology | Pharmacology | Biotechnology | Immunology | Developmental Biology | Cancer | Hematology | AI treatment | alternative therapies | splenic iron accumulation | Relieves Anemia | JAK | hepatic hepcidin | serum hepcidin | chemical property | hydrogen sulfide | SPRC | Traditional remedies | H 2 S synthases | -6 mRNA | H 2 S donor | H 2 S | serum IL -6 content | Mechanism study | erythrocyte membrane integrity | mouse AI model | Novel Hydrogen Sulfide Donor | transferrin saturation
    • FOR: 110309 Infectious Diseases | 60506 Virology | 39999 Chemical Sciences not elsewhere classified

<div><p>Anemia of inflammation (AI) is clinically prevalent and greatly threatens public health. Traditional remedies have raised controversy during clinical practice, calling for alternative therapies. We have recently found that hydrogen sulfide (H<sub>2</sub>S) inhib... View more
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