Glycan Masking of Plasmodium vivax Duffy Binding Protein for Probing Protein Binding Function and Vaccine Development

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Sampath, Sowmya; Carrico, Chris; Janes, Joel; Gurumoorthy, Sairam; Gibson, Claire; Melcher, Martin; E. Chitnis, Chetan; Wang, Ruobing; Schief, William R.; D. Smith, Joseph;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.ppat.1003420
  • Subject: Biological Sciences | Biochemistry | proteins | protein structure | immunology | Immune response | microbiology | Parasitology | glycan | masking | duffy | binding | probing

<div><p>Glycan masking is an emerging vaccine design strategy to focus antibody responses to specific epitopes, but it has mostly been evaluated on the already heavily glycosylated HIV gp120 envelope glycoprotein. Here this approach was used to investigate the binding i... View more
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