Glutamine Deprivation Induces Abortive S-Phase Rescued by Deoxyribonucleotides in K-Ras Transformed Fibroblasts

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Gaglio, Daniela; Soldati, Chiara; Vanoni, Marco; Alberghina, Lilia; Chiaradonna, Ferdinando;
(2009)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0004715
  • Subject: Biochemistry | Medicine | Cell Biology | glutamine | deprivation | induces | abortive | s-phase | rescued | deoxyribonucleotides | transformed | fibroblasts

<div><h3>Background</h3><p>Oncogene activation plays a role in metabolic reprogramming of cancer cells. We have previously shown that <em>K-ras</em> transformed fibroblasts have a stronger dependence on glycolysis and a reduced oxidative phosphorylation ability as compa... View more
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