Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites

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Amambua-Ngwa, Alfred; K. A. Tetteh, Kevin; Manske, Magnus; Gomez-Escobar, Natalia; B. Stewart, Lindsay; Elizabeth Deerhake, M.; H. Cheeseman, Ian; I. Newbold, Christopher; Holder, Anthony A.; Knuepfer, Ellen; Janha, Omar; Jallow, Muminatou; Campino, Susana; MacInnis, Bronwyn; P. Kwiatkowski, Dominic; Conway, David J.;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pgen.1002992
  • Subject: Microbiology | antigen | malaria | signatures | balancing | Genetics | Evolutionary Biology | genomic | parasites | Cancer | Immunology | characterization
    mesheuropmc: parasitic diseases

<div><p>Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiable signatures of balancing selection. To comprehensively survey for genes under such selection in the human malaria parasite <em>Plasmodium falciparum</em>, we ge... View more
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