Population Genomic Scan for Candidate Signatures of Balancing Selection to Guide Antigen Characterization in Malaria Parasites

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Amambua-Ngwa, Alfred ; K. A. Tetteh, Kevin ; Manske, Magnus ; Gomez-Escobar, Natalia ; B. Stewart, Lindsay ; Elizabeth Deerhake, M. ; H. Cheeseman, Ian ; I. Newbold, Christopher ; Holder, Anthony A. ; Knuepfer, Ellen ; Janha, Omar ; Jallow, Muminatou ; Campino, Susana ; MacInnis, Bronwyn ; P. Kwiatkowski, Dominic ; Conway, David J.
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pgen.1002992
  • Subject: Microbiology | antigen | malaria | signatures | balancing | Genetics | Evolutionary Biology | genomic | parasites | Cancer | Immunology | characterization
    mesheuropmc: parasitic diseases

<div><p>Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading to identifiable signatures of balancing selection. To comprehensively survey for genes under such selection in the human malaria parasite <em>Plasmodium falciparum</em>, we ge... View more
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