Impact on Malaria Parasite Multiplication Rates in Infected Volunteers of the Protein-in-Adjuvant Vaccine AMA1-C1/Alhydrogel+CPG 7909

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J. A. Duncan, Christopher; H. Sheehy, Susanne; J. Ewer, Katie; D. Douglas, Alexander; A. Collins, Katharine; D. Halstead, Fenella; C. Elias, Sean; J. Lillie, Patrick; Rausch, Kelly; Aebig, Joan; Miura, Kazutoyo; J. Edwards, Nick; D. Poulton, Ian; Hunt-Cooke, Angela; Porter, David W.; M. Thompson, Fiona; Rowland, Ros; J. Draper, Simon; C. Gilbert, Sarah; P. Fay, Michael; A. Long, Carole; Zhu, Daming; Wu, Yimin; B. Martin, Laura; Anderson, Charles F.; M. Lawrie, Alison; V. S. Hill, Adrian; D. Ellis, Ruth;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0022271
  • Subject: Microbiology | Biotechnology | Immunology | Cancer | malaria | parasite | multiplication | rates | infected | volunteers | protein-in-adjuvant | 7909

<div><h3>Background</h3><p>Inhibition of parasite growth is a major objective of blood-stage malaria vaccines. The <em>in vitro</em> assay of parasite growth inhibitory activity (GIA) is widely used as a surrogate marker for malaria vaccine efficacy in the down-selectio... View more
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