Inhibition of Atrogin-1/MAFbx Mediated MyoD Proteolysis Prevents Skeletal Muscle Atrophy In Vivo
Pierre Leibovitch, Marie
A. Leibovitch, Serge
- Publisher: Figshare
Medicine | Cell Biology | Molecular Biology | Physiology | Developmental Biology | inhibition | mediated | myod | proteolysis | prevents | skeletal | atrophy
<div><p>Ubiquitin ligase Atrogin1/Muscle Atrophy F-box (MAFbx) up-regulation is required for skeletal muscle atrophy but substrates and function during the atrophic process are poorly known. The transcription factor MyoD controls myogenic stem cell function and differen...