Inhibition of Atrogin-1/MAFbx Mediated MyoD Proteolysis Prevents Skeletal Muscle Atrophy In Vivo

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Lagirand-Cantaloube, Julie ; Cornille, Karen ; Csibi, Alfredo ; Batonnet-Pichon, Sabrina ; Pierre Leibovitch, Marie ; A. Leibovitch, Serge
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0004973
  • Subject: Medicine | Cell Biology | Molecular Biology | Physiology | Developmental Biology | inhibition | mediated | myod | proteolysis | prevents | skeletal | atrophy

<div><p>Ubiquitin ligase Atrogin1/Muscle Atrophy F-box (MAFbx) up-regulation is required for skeletal muscle atrophy but substrates and function during the atrophic process are poorly known. The transcription factor MyoD controls myogenic stem cell function and differen... View more
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