Optimising Controlled Human Malaria Infection Studies Using Cryopreserved P. falciparum Parasites Administered by Needle and Syringe

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H. Sheehy, Susanne; J. Spencer, Alexandra; D. Douglas, Alexander; Kim Lee Sim, B.; J. Longley, Rhea; J. Edwards, Nick; D. Poulton, Ian; Kimani, Domtila; R. Williams, Andrew; A. Anagnostou, Nicholas; Roberts, Rachel; Kerridge, Simon; Voysey, Merryn; R. James, Eric; F. Billingsley, Peter; Gunasekera, Anusha; M. Lawrie, Alison; L. Hoffman, Stephen; V. S. Hill, Adrian;
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0065960
  • Subject: Medicine | Biological Sciences | Computational biology | Population modeling | Infectious disease modeling | microbiology | Protozoology | Parastic protozoans | Plasmodium falciparum | Clinical research design | clinical trials | Prospective studies | Infectious diseases | Parasitic diseases | malaria | Tropical diseases (non-neglected) | Travel-associated diseases | optimising | controlled | studies | cryopreserved | parasites | administered | syringe

<div><p>Background</p><p>Controlled human malaria infection (CHMI) studies have become a routine tool to evaluate efficacy of candidate anti-malarial drugs and vaccines. To date, CHMI trials have mostly been conducted using the bite of infected mosquitoes, restricting t... View more
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