Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus

Collection UNKNOWN
S. Elshikha, Ahmed ; Lu, Yuanqing ; Chen, Mong-Jen ; Akbar, Mohammad ; Zeumer, Leilani ; Ritter, Andrea ; Elghamry, Hanaa ; Mahdi, Mahmoud A. ; Morel, Laurence ; Song, Sihong (2016)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0156583
  • Subject: Molecular Biology | lupus-prone mouse model | over-reactive dendritic cells | bm-derived dc differentiation | tlr 9 agonist | Ecology | haat treatment | function | Immunology | tlr 4 agonist | type 1 diabetes | il | alpha 1 antitrypsin inhibits dendritic cell activation | Developmental Biology | mrl | tnf | sle | lps | serum autoantibody levels | Hematology | Cell Biology | arthritis mouse models | Biochemistry | Cancer | ifn-i | activation
    • FOR: 69999 Biological Sciences not elsewhere classified
    mesheuropmc: skin and connective tissue diseases | immune system diseases

<div><p>Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution and considerable mortality and morbidity. Although the pathogenesis of this disease remains elusive, over-reactive dendritic cells (DCs) play a critical role in the diseas... View more
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