Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation and Attenuates Nephritis in a Mouse Model of Lupus

Collection UNKNOWN
S. Elshikha, Ahmed; Lu, Yuanqing; Chen, Mong-Jen; Akbar, Mohammad; Zeumer, Leilani; Ritter, Andrea; Elghamry, Hanaa; Mahdi, Mahmoud A.; Morel, Laurence; Song, Sihong;
(2016)
  • Publisher: Figshare
  • Related identifiers: doi: 10.1371/journal.pone.0156583
  • Subject: Molecular Biology | lupus-prone mouse model | over-reactive dendritic cells | BM-derived DC differentiation | TLR 9 agonist | Ecology | hAAT treatment | function | Immunology | TLR 4 agonist | type 1 diabetes | IL | Alpha 1 Antitrypsin Inhibits Dendritic Cell Activation | Developmental Biology | MRL | TNF | SLE | LPS | serum autoantibody levels | Hematology | Cell Biology | arthritis mouse models | Biochemistry | Cancer | IFN-I | activation
    • FOR: 69999 Biological Sciences not elsewhere classified
    mesheuropmc: skin and connective tissue diseases | immune system diseases

<div><p>Systemic lupus erythematosus (SLE) is an autoimmune disorder with a worldwide distribution and considerable mortality and morbidity. Although the pathogenesis of this disease remains elusive, over-reactive dendritic cells (DCs) play a critical role in the diseas... View more
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